Capturing Small Molecule Communication Between Tissues and Cells Using Imaging Mass Spectrometry
نویسندگان
چکیده
منابع مشابه
Screening and classifying small molecule inhibitors of amyloid formation using ion mobility spectrometry-mass spectrometry
The search for therapeutic agents that bind specifically to precursor protein conformations and inhibit amyloid assembly is an important challenge. Identifying such inhibitors is difficult because many protein precursors of aggregation are partially folded or intrinsically disordered, which rules out structure-based design. Furthermore, inhibitors can act by a variety of mechanisms, including s...
متن کاملChapter 13: Imaging of cells and tissues with mass spectrometry: adding chemical information to imaging.
Techniques that map the distribution of compounds in biological tissues can be invaluable in addressing a number of critical questions in biology and medicine. One of the newer methods, mass spectrometric imaging, has enabled investigation of spatial localization for a variety of compounds ranging from atomics to proteins. The ability of mass spectrometry to detect and differentiate a large num...
متن کاملSmall Molecule Identification with MOLGEN and Mass Spectrometry
This paper details the MOLGEN entries for the 2012 CASMI contest for small molecule identification to demonstrate structure elucidation using structure generation approaches. Different MOLGEN programs were used for different categories, including MOLGEN-MS/MS for Category 1, MOLGEN 3.5 and 5.0 for Category 2 and MOLGEN-MS for Categories 3 and 4. A greater focus is given to Categories 1 and 2, a...
متن کاملSmall Molecule Drug Imaging of Mouse Tissue by MALDI-TOF/TOF Mass Spectrometry and FTMS
Matrix Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry (MS) with a computer-controlled xy-stage in the ionization source can be used to detect the presence, approximate amount and location of small molecules, lipids, peptides and proteins in tissue samples through in vitro molecular imaging, often referred to as MALDI imaging. Both MALDI Time-of-flight/Time-of-flight (MALDI-TOF/T...
متن کاملSkin molecule maps using mass spectrometry.
Bouslimani et al. (1) have produced a wealth of new chemical information about human skin using impressive analytical chemistry, data handling, and big data representation. The authors examine skin cells, skin tissue and, overwhelmingly, swabs of selected regions of the skin. These samples, microbial strains, and beauty product samples were fractionated by chromatography and tandem MS (MS/MS) d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2019
ISSN: 1940-087X
DOI: 10.3791/59490